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Two subtle variants (V60L and I90M in the high-mobility group box) define inherited alleles shared by an XY sterile daughter and fertile father. Disclaimer: All models on this website are 18 years or older.This site has a zero-tolerance policy against illegal pornography.(sex determining region on Y chromosome) associated with somatic sex reversal provide a model for the perturbation of a genetic switch in organogenesis.Inherited alleles, associated with either testicular or ovarian differentiation, provide unique probes of threshold biochemical properties, defining mechanistic borders between functional and nonfunctional transcription factors.